The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

BACKGROUND: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even with germline mutated p53, these engineered melanomas present with variable...

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Detalhes bibliográficos
Main Authors: Yen, Jennifer, White, Richard M, Wedge, David C, Van Loo, Peter, de Ridder, Jeroen, Capper, Amy, Richardson, Jennifer, Jones, David, Raine, Keiran, Watson, Ian R, Wu, Chang-Jiun, Cheng, Jiqiu, Martincorena, Iñigo, Nik-Zainal, Serena, Mudie, Laura, Moreau, Yves, Marshall, John, Ramakrishna, Manasa, Tarpey, Patrick, Shlien, Adam, Whitmore, Ian, Gamble, Steve, Latimer, Calli, Langdon, Erin, Kaufman, Charles, Dovey, Mike, Taylor, Alison, Menzies, Andy, McLaren, Stuart, O’Meara, Sarah, Butler, Adam, Teague, Jon, Lister, James, Chin, Lynda, Campbell, Peter, Adams, David J, Zon, Leonard I, Patton, E Elizabeth, Stemple, Derek L, Futreal, P Andy
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983654/
https://ncbi.nlm.nih.gov/pubmed/24148783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-10-r113
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