The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

BACKGROUND: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even with germline mutated p53, these engineered melanomas present with variable...

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Autores principales: Yen, Jennifer, White, Richard M, Wedge, David C, Van Loo, Peter, de Ridder, Jeroen, Capper, Amy, Richardson, Jennifer, Jones, David, Raine, Keiran, Watson, Ian R, Wu, Chang-Jiun, Cheng, Jiqiu, Martincorena, Iñigo, Nik-Zainal, Serena, Mudie, Laura, Moreau, Yves, Marshall, John, Ramakrishna, Manasa, Tarpey, Patrick, Shlien, Adam, Whitmore, Ian, Gamble, Steve, Latimer, Calli, Langdon, Erin, Kaufman, Charles, Dovey, Mike, Taylor, Alison, Menzies, Andy, McLaren, Stuart, O’Meara, Sarah, Butler, Adam, Teague, Jon, Lister, James, Chin, Lynda, Campbell, Peter, Adams, David J, Zon, Leonard I, Patton, E Elizabeth, Stemple, Derek L, Futreal, P Andy
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983654/
https://ncbi.nlm.nih.gov/pubmed/24148783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-10-r113
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