Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.

SH-PTP1 is a protein tyrosine phosphatase (PTP) predominantly expressed in haematopoietic cells and containing two src homology-2 (SH2) domains. Here we report that SH-PTP1 is phosphorylated on both serine and tyrosine residues in response to thrombin or phorbol myristate acetate (PMA), which increa...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Li, R Y, Gaits, F, Ragab, A, Ragab-Thomas, J M, Chap, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC398365/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7781604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb07249.x
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