Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common human inherited diseases. Modifier genes seem to modulate the disease progression and might therefore be promising drug targets. Although a number of modifier loci have been already identified, no modifier gen...

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Detalhes bibliográficos
Main Authors: Boehn, Susanne N.E., Spahn, Sonja, Neudecker, Sabine, Keppler, Andrea, Bihoreau, Marie-Thérèse, Kränzlin, Bettina, Pandey, Priyanka, Hoffmann, Sigrid C., Li, Li, Torres, Vicente E., Gröne, Hermann-Josef, Gretz, Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983428/
https://ncbi.nlm.nih.gov/pubmed/23543593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gft014
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