Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor.

Using a three-dimensional model of G protein-coupled receptors (GPCR), we have previously succeeded in docking the neurohypophysial hormone arginine-vasopressin (AVP) into the V1a receptor. According to this model, the hormone is completely embedded in the transmembrane part of the receptor. Only th...

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Detalhes bibliográficos
Main Authors: Chini, B, Mouillac, B, Ala, Y, Balestre, M N, Trumpp-Kallmeyer, S, Hoflack, J, Elands, J, Hibert, M, Manning, M, Jard, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC398323/
https://ncbi.nlm.nih.gov/pubmed/7774575
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