The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

Nuclear receptors (NRs) bound to response elements mediate the effects of cognate ligands on gene expression. Their ligand-dependent activation function, AF-2, presumably acts on the basal transcription machinery through intermediary proteins/mediators. We have isolated a mouse nuclear protein, TIF1...

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Autores principales: Le Douarin, B, Zechel, C, Garnier, J M, Lutz, Y, Tora, L, Pierrat, P, Heery, D, Gronemeyer, H, Chambon, P, Losson, R
Formato: Artigo
Lenguaje:Inglês
Publicado: 1995
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC398302/
https://ncbi.nlm.nih.gov/pubmed/7744009
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