Erythrophagocytosis Enhances Heme-Dependent Cytotoxicity of Antimalarial Drugs in Canine Histiocytic Sarcoma Cell Line DH82

Antimalarial drugs, dihydroartemisinin (DHA) and artesunate (ATS), exhibit iron-dependent cytotoxicity in tumor cells. We hypothesized that erythrophagocytic uptake of heme-iron enhances the cytotoxicity of DHA and ATS. Erythrophagocytic (EP) treatment of the canine histiocytic sarcoma cell line DH8...

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Bibliographische Detailangaben
Hauptverfasser: CHIKAZAWA, Seishiro, KITAHARA, Yasunori, ANDO, Erika, HORI, Yasutomo, HOSHI, Fumio, KANAI, Kazutaka, ITO, Naoyuki, HIGUCHI, Seiichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Japanese Society of Veterinary Science 2013
Schlagworte:
Internal Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982809/
https://ncbi.nlm.nih.gov/pubmed/24065080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1292/jvms.13-0319
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