Nf1 Loss and Ras Hyperactivation in Oligodendrocytes Induce NOS-Driven Defects in Myelin and Vasculature

Patients with neurofibromatosis type 1 (NF1) and Costello syndrome Rasopathy have behavioral deficits. In NF1 patients, these may correlate with white matter enlargement and aberrant myelin. To model these features, we induced Nf1 loss or HRas hyperactivation in mouse oligodendrocytes. Enlarged brai...

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Main Authors: Mayes, Debra A., Rizvi, Tilat A., Titus-Mitchell, Haley, Oberst, Rachel, Ciraolo, Georgianne M., Vorhees, Charles V., Robinson, Andrew P., Miller, Stephen D., Cancelas, Jose A., Stemmer-Rachamimov, Anat O., Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982616/
https://ncbi.nlm.nih.gov/pubmed/24035394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.08.011
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