Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas

Our recent study demonstrated miR-15a/16-1 downregulation in mantle cell lymphoma (MCL). Here, we investigated mechanisms of miR-15a/16-1 transcriptional repression and its epigenetic regulation by c-Myc and histone deacetylase (HDAC) in MCL. c-Myc expression was detected in MCL cell lines and in th...

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Main Authors: Zhang, X, Chen, X, Lin, J, Lwin, T, Wright, G, Moscinski, LC, Dalton, WS, Seto, E, Wright, K, Sotomayor, E, Tao, J
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982396/
https://ncbi.nlm.nih.gov/pubmed/22002311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.470
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