Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila

Cytosolic nucleotidase II (cN-II) from Legionella pneumophila (Lp) catalyzes the hydrolysis of GMP and dGMP displaying sigmoidal curves while catalysis of IMP hydrolysis displayed a biphasic curve in the initial rate versus substrate concentration plots. Allosteric modulators of mammalian cN-II did...

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Main Authors: Srinivasan, Bharath, Forouhar, Farhad, Shukla, Arpit, Sampangi, Chethana, Kulkarni, Sonia, Abashidze, Mariam, Seetharaman, Jayaraman, Lew, Scott, Mao, Lei, Acton, Thomas B., Xiao, Rong, Everett, John K., Montelione, Gaetano T., Tong, Liang, Balaram, Hemalatha
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982195/
https://ncbi.nlm.nih.gov/pubmed/24456211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12727
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