Sustained resistance to acute MPTP toxicity by hypothalamic dopamine neurons following chronic neurotoxicant exposure is associated with sustained up-regulation of parkin protein

Hypothalamic tuberoinfundibular dopamine (TIDA) neurons remain unaffected in Parkinson disease (PD) while there is significant degeneration of midbrain nigrostriatal dopamine (NSDA) neurons. A similar pattern of susceptibility is observed following acute exposure to the neurotoxicant 1-methyl-4-phen...

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Detalhes bibliográficos
Main Authors: Benskey, Matthew, Lee, Ki Yong, Parikh, Kevin, Lookingland, Keith J., Goudreau, John L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982185/
https://ncbi.nlm.nih.gov/pubmed/23643664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2013.04.002
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