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Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids
Inadequate immunomodulatory potency of mesenchymal stem cells (MSC) may limit their therapeutic efficacy. We report glucocorticoid steroids augment MSC expression and activity of indoleamine-2,3-dioxygenase (IDO), a primary mediator of MSC immunomodulatory function. This effect depends on signaling...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3982175/ https://ncbi.nlm.nih.gov/pubmed/24717973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04645 |
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