OAT3-mediated extrusion of the (99m)Tc-ECD metabolite in the mouse brain

After administration of the (99m)Tc complex with N,N'-1,2-ethylenediylbis-L-cysteine diethyl ester ((99m)Tc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat. Here, we investigate the involvement of metabolite extrusion by or...

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Bibliografiske detaljer
Main Authors: Kikuchi, Tatsuya, Okamura, Toshimitsu, Wakizaka, Hidekatsu, Okada, Maki, Odaka, Kenichi, Yui, Joji, Tsuji, Atsushi B, Fukumura, Toshimitsu, Zhang, Ming-Rong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Brief Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982094/
https://ncbi.nlm.nih.gov/pubmed/24496177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.20
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