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Measures of gene expression in sputum cells can identify T(H)2-high and T(H)2-low subtypes of asthma

BACKGROUND: The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and Serpin β2 (SERPINB2) in airway epithelial brushings is used to classify asthma into T(H)2-high and T(H)2-low endotypes. Little is known about the utility of gene profiling in sputum as a molecular phenotyping me...

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Auteurs principaux: Peters, Michael C., Mekonnen, Zesemayat K., Yuan, Shaopeng, Bhakta, Nirav R., Woodruff, Prescott G., Fahy, John V.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981552/
https://ncbi.nlm.nih.gov/pubmed/24075231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.07.036
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