Structural Stereochemistry of Androstene Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoid Receptors

DHEA, 17α-AED, 17β-AED, and 17β-AET exhibit strong biological activity that has been attributed to androgenic, estrogenic, or antiglucocorticoid activity in vivo and in vitro. This study compared DHEA, 17α-AED, 17β-AED, and 17β-AET for their ability to activate the human AR, ER, and GR and determine...

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Detalhes bibliográficos
Main Authors: Shaak, Thomas L., Wijesinghe, Dayanjan S., Chalfant, Charles E., Diegelmann, Robert F., Ward, Kevin R., Loria, Roger M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981456/
https://ncbi.nlm.nih.gov/pubmed/24729874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/203606
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