The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

Previous studies have suggested that the vav protooncogene plays an important role in hematopoiesis. To study this further, we have ablated the vav protooncogene by homologous recombination in embryonic stem (ES) cells. Homozygous vav (-/-) ES clones differentiate normally in culture and generate ce...

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Autori principali: Zmuidzinas, A, Fischer, K D, Lira, S A, Forrester, L, Bryant, S, Bernstein, A, Barbacid, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC398046/
https://ncbi.nlm.nih.gov/pubmed/7828581
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