The Inducible Nitric-oxide Synthase (iNOS)/Src Axis Mediates Toll-like Receptor 3 Tyrosine 759 Phosphorylation and Enhances Its Signal Transduction, Leading to Interferon-β Synthesis in Macrophages

Double-stranded RNA (dsRNA) induces phosphorylation of Toll-like receptor 3 (TLR3) at tyrosine 759 and subsequently triggers signaling pathways to promote interferon-β (IFN-β) production. In this study, we found that dsRNA stimulation induces biphasic TLR3 Tyr-759 phosphorylation in macrophages. In...

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Autores principales: Hsieh, Ming-Yu, Chang, Miao Ying, Chen, Yen-Jen, Li, Yung Kuo, Chuang, Tsung-Hsien, Yu, Guann-Yi, Cheung, Chun Hei Antonio, Chen, Hui-Chen, Maa, Ming-Chei, Leu, Tzeng-Horng
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979412/
https://ncbi.nlm.nih.gov/pubmed/24526685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508663
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