Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

BACKGROUND: Hypoxia induces an inflammatory response in the lung manifested by alternative activation of macrophages with elevation of pro-inflammatory mediators that are critical for the later development of hypoxic pulmonary hypertension (HPH). Mesenchymal stromal cell (MSC) transplantation inhibi...

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Hauptverfasser: Lee, Changjin, Mitsialis, S. Alex, Aslam, Muhammad, Vitali, Sally H., Vergadi, Eleni, Konstantinou, Georgios, Sdrimas, Konstantinos, Fernandez-Gonzalez, Angeles, Kourembanas, Stella
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979353/
https://ncbi.nlm.nih.gov/pubmed/23114789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.114173
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