Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis

INTRODUCTION: Animal models currently used in osteoarthritis-associated pain research inadequately reproduce the initiating events and structural pathology of human osteoarthritis. Conversely, intra-articular injection of collagenase is a structurally relevant model, as it induces articular degenera...

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Autors principals: Adães, Sara, Mendonça, Marcelo, Santos, Telmo N, Castro-Lopes, José M, Ferreira-Gomes, Joana, Neto, Fani L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979102/
https://ncbi.nlm.nih.gov/pubmed/24423138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4436
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