Immunoaffinity purification of factor IX (Christmas factor) by using conformation-specific antibodies directed against the factor IX-metal complex.

Factor IX is a vitamin K-dependent blood clotting zymogen that is functionally defective or absent in patients with hemophilia B. A method of immunoaffinity chromatography has been developed for a one-step high yield purification of factor IX directly from plasma. The technique utilizes conformation...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Liebman, H A, Limentani, S A, Furie, B C, Furie, B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1985
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397892/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2408269/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.11.3879
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