Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

The tumor-promoting phorbol diester 4 beta-phorbol 12-myristate 13-acetate (PMA) inhibited mobilization of intracellular Ca2+ in platelets by thrombin (also trypsin and 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine). PMA was effective over the same concentration range that activates protein kinase...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Zavoico, G B, Halenda, S P, Sha'afi, R I, Feinstein, M B
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1985
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397887/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2987951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.11.3859
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