Transduction of Fetal Mice With a Feline Lentiviral Vector Induces Liver Tumors Which Exhibit an E2F Activation Signature

Lentiviral vectors are widely used in basic research and clinical applications for gene transfer and long-term expression; however, safety issues have not yet been completely resolved. In this study, we characterized hepatocarcinomas that developed in mice 1 year after in utero administration of a f...

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Bibliographic Details
Main Authors: Condiotti, Reba, Goldenberg, Daniel, Giladi, Hilla, Schnitzer-Perlman, Temima, Waddington, Simon N, Buckley, Suzanne MK, Heim, Denise, Cheung, Wing, Themis, Matthew, Coutelle, Charles, Simerzin, Alina, Osejindu, Emma, Wege, Henning, Themis, Michael, Galun, Eithan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978808/
https://ncbi.nlm.nih.gov/pubmed/23982166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.193
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