Regenerating Cartilages by Engineered ASCs: Prolonged TGF-β3/BMP-6 Expression Improved Articular Cartilage Formation and Restored Zonal Structure

Adipose-derived stem cells (ASCs) hold promise for cartilage regeneration but their chondrogenesis potential is inferior. Here, we used a baculovirus (BV) system that exploited FLPo/Frt-mediated transgene recombination and episomal minicircle formation to genetically engineer rabbit ASCs (rASCs). Th...

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Autori principali: Lu, Chia-Hsin, Yeh, Tsung-Szu, Yeh, Chia-Lin, Fang, Yu-Hua Dean, Sung, Li-Yu, Lin, Shih-Yeh, Yen, Tzu-Chen, Chang, Yu-Han, Hu, Yu-Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978803/
https://ncbi.nlm.nih.gov/pubmed/23851345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.165
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