Molecular targeting of hepatocyte growth factor by an antagonist, NK4, in the treatment of rheumatoid arthritis

INTRODUCTION: Hepatocyte growth factor (HGF) is a potent proangiogenic molecule that induces neovascularization. The HGF antagonist, NK4, competitively antagonizes HGF binding to its receptor. In the present study, we determined the inhibitory effect of NK4 in a rheumatoid arthritis (RA) model using...

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Autors principals: Tsunemi, Sachi, Iwasaki, Tsuyoshi, Kitano, Sachie, Matsumoto, Kunio, Takagi-Kimura, Misato, Kubo, Shuji, Tamaoki, Tomoko, Sano, Hajime
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978668/
https://ncbi.nlm.nih.gov/pubmed/23876175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4252
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