Application of the principle of linked functions to ATP-driven ion pumps: kinetics of activation by ATP.
If a ligand binds with unequal affinity to two distinct states of a protein, then the equilibrium between the two states becomes a function of the concentration of the ligand. A necessary consequence is that the ligand must also affect the forward and/or reverse rate constants for transition between...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1985
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397845/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2987939/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.11.3658 |
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