DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation

Prostate cancer (CaP) is mostly composed of luminal-like differentiated cells, but contains a small subpopulation of basal cells (including stem-like cells), which can proliferate and differentiate into luminal-like cells. In cancers, CpG island hypermethylation has been associated with gene downreg...

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Main Authors: Pellacani, D, Kestoras, D, Droop, A P, Frame, F M, Berry, P A, Lawrence, M G, Stower, M J, Simms, M S, Mann, V M, Collins, A T, Risbridger, G P, Maitland, N J
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978305/
https://ncbi.nlm.nih.gov/pubmed/24464224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.202
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