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Dynamin 2–dependent endocytosis is required for sustained S1PR1 signaling
Sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) is critical for lymphocyte egress from lymphoid organs. Lymphocytes encounter low S1P concentrations near exit sites before transmigration, yet S1PR1 signaling is rapidly terminated after exposure to S1P. How lymphocytes maintain S1PR1 signaling in a...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3978280/ https://ncbi.nlm.nih.gov/pubmed/24638168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131343 |
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