Endotoxin Induces Fibrosis in Vascular Endothelial Cells through a Mechanism Dependent on Transient Receptor Protein Melastatin 7 Activity

The pathogenesis of systemic inflammatory diseases, including endotoxemia-derived sepsis syndrome, is characterized by endothelial dysfunction. It has been demonstrated that the endotoxin lipopolysaccharide (LPS) induces the conversion of endothelial cells (ECs) into activated fibroblasts through en...

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Hauptverfasser: Echeverría, Cesar, Montorfano, Ignacio, Hermosilla, Tamara, Armisén, Ricardo, Velásquez, Luis A., Cabello-Verrugio, Claudio, Varela, Diego, Simon, Felipe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978016/
https://ncbi.nlm.nih.gov/pubmed/24710004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094146
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