Systematic Study on Genetic and Epimutational Profile of a Cohort of Amsterdam Criteria-Defined Lynch Syndrome in Singapore

BACKGROUND: Germline defects of mismatch repair (MMR) genes underlie Lynch Syndrome (LS). We aimed to gain comprehensive genetic and epigenetic profiles of LS families in Singapore, which will facilitate efficient molecular diagnosis of LS in Singapore and the region. METHODS: Fifty nine unrelated f...

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Autores principales: Liu, Yanqun, Chew, Min Hoe, Goh, Xue Wei, Tan, Soo Yong, Loi, Carol Tien Tau, Tan, Yuen Ming, Law, Hai Yang, Koh, Poh Koon, Tang, Choong Leong
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978005/
https://ncbi.nlm.nih.gov/pubmed/24710284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094170
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