Optimisation of an immunohistochemistry method for the determination of androgen receptor expression levels in circulating tumour cells

BACKGROUND: AZD3514 inhibits and down regulates the androgen receptor (AR) and has undergone clinical trials in prostate cancer. To provide proof-of-mechanism (POM) in patients, an immunohistochemistry (IHC) method for determination of AR in circulating tumour cells (CTC) was developed and validated...

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Main Authors: Cummings, Jeffrey, Sloane, Robert, Morris, Karen, Zhou, Cong, Lancashire, Matt, Moore, David, Elliot, Tony, Clarke, Noel, Dive, Caroline
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Technical Advance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977890/
https://ncbi.nlm.nih.gov/pubmed/24674711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-226
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