Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking

Cholinesterases (ChEs) play a vital role in the regulation of cholinergic transmission. The inhibition of ChEs is considered to be involved in increasing acetylcholine level in the brain and thus has been implicated in the treatment of Alzheimer’s disease. We have designed and synthesized a series o...

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Detalhes bibliográficos
Main Authors: Yar, Muhammad, Bajda, Marek, Mehmood, Rana Atif, Sidra, Lala Rukh, Ullah, Nisar, Shahzadi, Lubna, Ashraf, Muhammad, Ismail, Tayaba, Shahzad, Sohail Anjum, Khan, Zulfiqar Ali, Naqvi, Syed Ali Raza, Mahmood, Nasir
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Science Publishers Ltd 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977535/
https://ncbi.nlm.nih.gov/pubmed/24719609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/15701808113106660078
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