Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication

During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to restore chromatin organization. Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-Like Kinases (TLKs). Here, we identify TLK phosphorylation sites by mass spectrometry and...

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Detalhes bibliográficos
Main Authors: Klimovskaia, Ilnaz M, Young, Clifford, Strømme, Caroline B, Menard, Patrice, Jasencakova, Zuzana, Mejlvang, Jakob, Ask, Katrine, Ploug, Michael, Nielsen, Michael L, Jensen, Ole N, Groth, Anja
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977046/
https://ncbi.nlm.nih.gov/pubmed/24598821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4394
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