5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity

Demethylating agent, 5-Azacytidine (5-Aza), has been shown to be active in treatment of myeloid malignancies. 5-Aza enhances anticancer immunity, by increasing expression of tumor-associated antigens. However, the impact of 5-Aza immune responses remains poorly understood. Here, T-cell mediated tumo...

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Autori principali: Stübig, Thomas, Badbaran, Anita, Luetkens, Tim, Hildebrandt, York, Atanackovic, Djordje, Binder, Thomas M. C., Fehse, Boris, Kröger, Nicolaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976863/
https://ncbi.nlm.nih.gov/pubmed/24757283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/418292
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