Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)-modified alginate hydrogels

Recombinant proteins and cytokines are under broad preclinical and clinical investigation to promote angiogenesis, but their success is limited by ineffective delivery, lack of long-term stability, and excessive cost. Mesenchymal stem/stromal cells (MSC) secrete bioactive trophic factors, and thus,...

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Hauptverfasser: Jose, Soumia, Hughbanks, Marissa L., Binder, Bernard Y.K., Ingavle, Ganesh C., Leach, J. Kent
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976757/
https://ncbi.nlm.nih.gov/pubmed/24468583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2014.01.020
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