RESEARCH PAPER Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes

BACKGROUND AND PURPOSE: Dynamin-related protein 1 (Drp1) mediates mitochondrial fission and is thought to promote Bax/Bak-induced cytochrome c release during apoptosis. Conformationally active Bax, Bak and Bax/Bak-activating BH3-only proteins, such as Bim, are restrained by anti-apoptotic Bcl-2 prot...

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Detalhes bibliográficos
Main Authors: Clerc, P, Ge, S X, Hwang, H, Waddell, J, Roelofs, B A, Karbowski, M, Sesaki, H, Polster, B M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Themed Issue: Mitochondrial Pharmacology: Energy, Injury & Beyond
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976617/
https://ncbi.nlm.nih.gov/pubmed/24206264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12515
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