Modulation of HIV-1-Induced Activation of Plasmacytoid Dendritic Cells by 6-Desfluoroquinolones

Chronic activation of plasmacytoid dendritic cells (pDCs) is an important contributor to the immunopathogenesis of HIV infection. The quinolone derivative chloroquine (CQ) prevents endosomal acidification, required for toll-like receptor sensing of HIV by pDCs, and is currently under clinical trial...

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Hlavní autoři: Royle, Caroline M., Tsai, Ming-Han, Tabarrini, Oriana, Massari, Serena, Graham, David R., Aquino, Veronica N., Boasso, Adriano
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2014
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976578/
https://ncbi.nlm.nih.gov/pubmed/24229417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2013.0154
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