Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

The inducible resistance to alkylation mutagenesis and killing in Escherichia coli (the adaptive response) is controlled by the ada gene. The Ada protein acts both as a positive regulator of the response and as a DNA repair enzyme, correcting premutagenic O6-alkylguanine in DNA by suicidal transfer...

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Hauptverfasser: Demple, B, Sedgwick, B, Robins, P, Totty, N, Waterfield, M D, Lindahl, T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1985
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC397630/
https://ncbi.nlm.nih.gov/pubmed/3887409
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