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Impaired natural killer cell self-education and “missing-self” responses in Ly49-deficient mice
Ly49-mediated recognition of MHC-I molecules on host cells is considered vital for natural killer (NK)–cell regulation and education; however, gene-deficient animal models are lacking because of the difficulty in deleting this large multigene family. Here, we describe NK gene complex knockdown (NKC(...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976224/ https://ncbi.nlm.nih.gov/pubmed/22661698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-408732 |
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