Impaired natural killer cell self-education and “missing-self” responses in Ly49-deficient mice

Ly49-mediated recognition of MHC-I molecules on host cells is considered vital for natural killer (NK)–cell regulation and education; however, gene-deficient animal models are lacking because of the difficulty in deleting this large multigene family. Here, we describe NK gene complex knockdown (NKC(...

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Autori principali: Bélanger, Simon, Tu, Megan M., Rahim, Mir Munir Ahmed, Mahmoud, Ahmad B., Patel, Rajen, Tai, Lee-Hwa, Troke, Angela D., Wilhelm, Brian T., Landry, Josette-Renée, Zhu, Qinzhang, Tung, Kenneth S., Raulet, David H., Makrigiannis, Andrew P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976224/
https://ncbi.nlm.nih.gov/pubmed/22661698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-408732
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