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gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.
A methotrexate (MTX) analog containing fluorine at the gamma-carbon of the glutamate moiety, gamma-fluoromethotrexate (FMTX), has been synthesized and evaluated for its biochemical and pharmacological properties. FMTX inhibition of dihydrofolate reductase from several sources is nearly equivalent to...
में बचाया:
मुख्य लेखकों: | , , , , |
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स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
1985
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC397611/ https://ncbi.nlm.nih.gov/pubmed/2581252 |
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