Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer

BACKGROUND: Hamartin (TSC1) and tuberin (TSC2), encoded by the tuberous sclerosis complex (TSC) genes, form a tumor-suppressor heterodimer which is implicated in PI3K-Akt signaling and acts as a functional inhibitor of the mammalian target of rapamycin (mTOR). Dysregulation of mTOR has been assigned...

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Detalhes bibliográficos
Main Authors: Fuchs, Angela, König, Katharina, Heukamp, Lukas C, Fassunke, Jana, Kirfel, Jutta, Huss, Sebastian, Becker, Albert J, Büttner, Reinhard, Majores, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975884/
https://ncbi.nlm.nih.gov/pubmed/24593867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1746-1596-9-48
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