USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors

Lysine 63 (K63)-linked ubiquitination of RIG-I plays a critical role in the activation of type I interferon pathway, yet the molecular mechanism responsible for its deubiquitination is still poorly understood. Here we report that the deubiquitination enzyme ubiquitin-specific protease 3 (USP3) negat...

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Main Authors: Cui, Jun, Song, Yanxia, Li, Yinyin, Zhu, Qingyuan, Tan, Peng, Qin, Yunfei, Wang, Helen Y, Wang, Rong-Fu
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2014
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975496/
https://ncbi.nlm.nih.gov/pubmed/24366338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.170
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