Mosaic Copy Number Variation in Human Neurons

We used single cell genomic approaches to map DNA copy number variation (CNV) in neurons obtained from human induced pluripotent stem cell (hiPSC) lines and post-mortem human brains. We identified aneuploid neurons as well as numerous subchromosomal CNVs in euploid neurons. Neurotypic hiPSC-derived...

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Detalhes bibliográficos
Main Authors: McConnell, Michael J., Lindberg, Michael R., Brennand, Kristen J., Piper, Julia C., Voet, Thierry, Cowing-Zitron, Chris, Shumilina, Svetlana, Lasken, Roger S., Vermeesch, Joris, Hall, Ira M., Gage, Fred H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975283/
https://ncbi.nlm.nih.gov/pubmed/24179226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1243472
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