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The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?

The emergence of drug-resistant pathogens poses a major threat to public health. Although influenced by multiple factors, high-level resistance is often associated with mutations in target-encoding or related genes. The fitness cost of these mutations is, in turn, a key determinant of the spread of...

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Hlavní autoři: Koch, Anastasia, Mizrahi, Valerie, Warner, Digby F
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975073/
https://ncbi.nlm.nih.gov/pubmed/26038512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2014.17
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