A Highly Conserved Toxo1 Haplotype Directs Resistance to Toxoplasmosis and Its Associated Caspase-1 Dependent Killing of Parasite and Host Macrophage

Natural immunity or resistance to pathogens most often relies on the genetic make-up of the host. In a LEW rat model of refractoriness to toxoplasmosis, we previously identified on chromosome 10 the Toxo1 locus that directs toxoplasmosis outcome and controls parasite spreading by a macrophage-depend...

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Autors principals: Cavailles, Pierre, Flori, Pierre, Papapietro, Olivier, Bisanz, Cordelia, Lagrange, Dominique, Pilloux, Ludovic, Massera, Céline, Cristinelli, Sara, Jublot, Delphine, Bastien, Olivier, Loeuillet, Corinne, Aldebert, Delphine, Touquet, Bastien, Fournié, Gilbert J., Cesbron-Delauw, Marie France
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974857/
https://ncbi.nlm.nih.gov/pubmed/24699513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004005
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