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Treatment of Erythrocytes with the 2-Cys Peroxiredoxin Inhibitor, Conoidin A, Prevents the Growth of Plasmodium falciparum and Enhances Parasite Sensitivity to Chloroquine

The human erythrocyte contains an abundance of the thiol-dependant peroxidase Peroxiredoxin-2 (Prx2), which protects the cell from the pro-oxidant environment it encounters during its 120 days of life in the blood stream. In malarial infections, the Plasmodium parasite invades red cells and imports...

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書誌詳細
主要な著者: Brizuela, Mariana, Huang, Hong Ming, Smith, Clare, Burgio, Gaetan, Foote, Simon J., McMorran, Brendan J.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974718/
https://ncbi.nlm.nih.gov/pubmed/24699133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092411
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