DNA Repair Pathway Selection Caused by Defects in TEL1, SAE2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures

Whole genome sequencing of cancer genomes has revealed a diversity of recurrent gross chromosomal rearrangements (GCRs) that are likely signatures of specific defects in DNA damage response pathways. However, inferring the underlying defects has been difficult due to insufficient information relatin...

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Bibliografiske detaljer
Main Authors: Putnam, Christopher D., Pallis, Katielee, Hayes, Tikvah K., Kolodner, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974649/
https://ncbi.nlm.nih.gov/pubmed/24699249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004277
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