DNA Repair Pathway Selection Caused by Defects in TEL1, SAE2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures

Whole genome sequencing of cancer genomes has revealed a diversity of recurrent gross chromosomal rearrangements (GCRs) that are likely signatures of specific defects in DNA damage response pathways. However, inferring the underlying defects has been difficult due to insufficient information relatin...

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Autors principals: Putnam, Christopher D., Pallis, Katielee, Hayes, Tikvah K., Kolodner, Richard D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974649/
https://ncbi.nlm.nih.gov/pubmed/24699249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004277
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