Intradimerically tethered DNA topoisomerase II is catalytically active in DNA transport.
A covalently cross-linked dimer of yeast DNA topoisomerase II was created by fusing the enzyme with the GCN4 leucine zipper followed by two glycines and a cysteine. Upon oxidation of the chimeric protein, a disulfide bond forms between the two carboxyl termini, covalently and intradimerically cross-...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
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| Päätekijä: | |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
1996
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39745/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8610153/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.7.2975 |
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