Deletion of 43 amino acids in the NH2-terminal half of the large tumor antigen of simian virus 40 results in a non-karyophilic protein capable of transforming established cells.

We have characterized a simian virus 40 (SV40) mutant, derived from the viral DNA insertion present in simian cell transformants, which carries a deletion affecting the NH2-terminal region of the SV40 large tumor antigen. This mutant protein is 6% smaller than normal, has lost the typical nuclear lo...

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Bibliographic Details
Main Authors: Fischer-Fantuzzi, L, Vesco, C
Format: Artigo
Language:Inglês
Published: 1985
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC397438/
https://ncbi.nlm.nih.gov/pubmed/2984671
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