Rationale, design, and baseline characteristics of a clinical trial for prevention of atherosclerosis in patients with insulin-treated type 2 diabetes mellitus using DPP-4 inhibitor: the Sitagliptin Preventive study of Intima-media thickness Evaluation (SPIKE)

BACKGROUND: Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is currently used to achieve glycemic targets in patients with type 2 diabetes mellitus (T2DM). The addition of DPP-4 inhibitors to ongoing insulin therapy is expected to reduce insulin dosage, leading to a reduction in the frequen...

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Detalhes bibliográficos
Main Authors: Mita, Tomoya, Katakami, Naoto, Shiraiwa, Toshihiko, Yoshii, Hidenori, Onuma, Tomio, Kuribayashi, Nobuichi, Osonoi, Takeshi, Kaneto, Hideaki, Kosugi, Keisuke, Umayahara, Yutaka, Yamamoto, Tsunehiko, Matsumoto, Kazunari, Yokoyama, Hiroki, Tsugawa, Mamiko, Gosho, Masahiko, Shimomura, Iichiro, Watada, Hirotaka
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973974/
https://ncbi.nlm.nih.gov/pubmed/24607023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1758-5996-6-35
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