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Kinase-Independent Mechanisms of Resistance of Leukemia Stem Cells to Tyrosine Kinase Inhibitors
Tyrosine kinase inhibitors such as imatinib mesylate have changed the clinical course of chronic myeloid leukemia; however, the observation that these inhibitors do not target the leukemia stem cell implies that patients need to maintain lifelong therapy. The mechanism of this phenomenon is unclear:...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
AlphaMed Press
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973707/ https://ncbi.nlm.nih.gov/pubmed/24598782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0159 |
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