Direct, Acute Effects of Klotho and FGF23 on Vascular Smooth Muscle and Endothelium

Chronic kidney disease (CKD) is regarded as a state of Klotho deficiency and FGF23 excess. In patients with CKD a strong association has been found between increased serum FGF23 and mortality risk, possibly via enhanced atherosclerosis, vascular stiffness, and vascular calcification. The aim of this...

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Bibliographic Details
Main Authors: Six, Isabelle, Okazaki, Hirokazu, Gross, Priscilla, Cagnard, Joanna, Boudot, Cédric, Maizel, Julien, Drueke, Tilman B., Massy, Ziad A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973676/
https://ncbi.nlm.nih.gov/pubmed/24695641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093423
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